USS Colorado may refer to the following ships of the United States Navy:
, a three-masted steam screw frigate in commission from 1858–1876 , a Pennsylvania-class armored cruiser in commission from 1905–1927 , a Colorado-class battleship in commission from 1923–1947 , a Virginia-class nuclear-powered fast attack submarine commissioned in 2018, in active service
In fiction: USS Colorado (SSBN-753), a fictional Ohio-class submarine featured in the 2012 TV series Last Resort