Mechanicsburg may refer to:
Places In the United States: Mechanicsburg, Illinois Mechanicsburg Township, Sangamon County, Illinois Mechanicsburg, Boone County, Indiana Mechanicsburg, Henry County, Indiana Mechanicsburg, Ohio, in Champaign County Mechanicsburg, Crawford County, Ohio Mechanicsburg, Pennsylvania Mechanicsburg, Virginia Mechanicsburg, West Virginia
Fiction Mechanicsburg, a fictional European city in the comic series Girl Genius