Methanol dehydrogenase (cytochrome c) (, methanol dehydrogenase, MDH) is an enzyme with systematic name methanol:cytochrome c oxidoreductase. This enzyme catalyses the following chemical reaction

a primary alcohol + 2 ferricytochrome cL an aldehyde + 2 ferrocytochrome cL + 2 H+

A periplasmic quinoprotein alcohol dehydrogenase is only present in methylotrophic bacteria.

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