Leche is a surname. Notable people with the surname include:
James Leche (born by 1518–54), Welsh MP Joan Leche (c. 1450 – 1530), English benefactress Johan Leche (1704–1764), Swedish physician and naturalist Paul Leche (1857–1938), Justice of the Louisiana Supreme Court Richard W. Leche (1898–1965), governor of Louisiana, 1936–1939 Roger Leche (died 1416), English courtier, MP and Lord High Treasurer Thomas Leche (1581–1646), Archdeacon of Wilt Wilhelm Leche (1850–1927), Swedish zoologist