George Henderson may refer to:
Academia and science George Henderson (architect) (1846–1905), Scottish architect George Washington Henderson (1850–1936), American academic G. G. Henderson (George Gerald Henderson, 1862–1942), chemist and professor George Henderson (scholar) (1866–1912), Gaelic scholar George Cockburn Henderson (1870–1944), Australian academic in the Universities of Sydney and Adelaide George D. S. Henderson (born 1931), art historian, author, and emeritus Professor of Medieval Art at the University of Cambridge George Robin Henderson (1941–2016), Scottish mathematician
Arts and entertainment George Wylie Henderson (1904–1965), American author of the Harlem Renaissance George Henderson (cartoonist) (1911–1985), New Zealand cartoonist
Military George Henderson (British Army officer) (1783–1855), Scottish lieutenant-colonel and royal engineer George Francis Robert Henderson (1854–1903), British soldier and military author George R. Henderson (1893–1964), World War II-era officer in United States Navy George Stuart Henderson (1893–1920), recipient of the Victoria Cross George Henderson (GC), British recipient of the George Cross
Politics George Henderson (Australian politician) (1857–1933), Australian politician George Henderson (Manitoba politician) (1916–2008), former MLA in Manitoba George Henderson (Northern Ireland politician) (), former Member of the Northern Ireland Parliament for Antrim George Henderson (Prince Edward Island politician) (1935–2020), former Member of Parliament in Canada
Sports George Henderson (footballer, born 1873), Scottish footballer George Henderson (footballer, born 1880) (1880–1930), Scottish footballer George Henderson (footballer, born 1902) (1902–1975), Scottish footballer for Sunderland Geordie Henderson (1897–1953), Scottish footballer Krazy George Henderson (born 1944), American cheerleader Rube Henderson (George E. Henderson, 1894–1978), American baseball player
Religion George Henderson (bishop) (1922–1997), Episcopal bishop and Primus in Scotland G. D. Henderson (1888–1957), Scottish historian and minister of the Church of Scotland
Fictional characters George Henderson, in the 1987 film Harry and the Hendersons George Henderson (River City), Scottish soap opera character
Other uses George R. Henderson Medal, given by the Franklin Institute for improvements to railway engineering