PLE may refer to:
Photoluminescence excitation Pig-liver esterase Pittsburgh and Lake Erie Railroad, P&LE Polymorphous light eruption, a skin condition caused by sunlight Public legal education Protein losing enteropathy Primary Leaving Examinations, in education in Uganda State of Palestine, IOC country code Pollokshields East railway station, Glasgow, Scotland, National Rail station code
See also Plé, a surname