Region 1 or Region I may refer to:
Government Region 1, Northwest Territories, a Statistics Canada census division Former Region 1 (Johannesburg), an administrative district in the city of Johannesburg, South Africa, from 2000 to 2006 Ilocos Region (designated as Region I), an administrative region in the Philippines Region 1, an administrative region in Iran
Technology DVD region 1, one of the DVD regions ITU Region 1, consisting of the Americas