Didenko is a Ukrainian surname. Notable people with the surname include:
Alexei Didenko (born 1983), Russian politician Anatoliy Didenko (born 1982), Ukrainian footballer Ihor Didenko (born 1967), Ukrainian politician Nadiya Didenko (born 1986), Ukrainian freestyle skier Valeri Didenko (born 1946), Soviet canoeist Vladyslav Didenko (born 1992), Ukrainian politician Yulia Didenko (born 1978), Ukrainian politician