Wassef is both a given name and a surname.

Notable people with the given name include: Charlotte Wassef (1912–1988), Egyptian beauty queen Muna Wassef (born 1942), Syrian Kurdish stage, film and television actress Ramses Wissa Wassef (1911–1974), Egyptian architect and professor of art and architecture Wadida Wassef (born 1926), Egyptian writer and translator

Notable people with the surname include: Wassef Boutros-Ghali (1924-2023), Egyptian architect and painter Wassef El Harakeh, Lebanese lawyer and political activist Wassef Ali Hassoun (born 1980), United States Marine Wassef Hinein, Egyptian Coptic Christian activist

See also Ramses Wissa Wassef Art Center, art center near Cairo, Egypt