Big Balls may refer to:
Music "Big Balls", a song from the album Dirty Deeds Done Dirt Cheap by AC/DC Big Balls, an album by Big Balls and the Great White Idiot
Entertainment Big Balls, an obstacle in the game show Wipeout Bigballs Media, the owner of COPA90
People Edward Coristine, an American software engineer and political figure with the pseudonym "Big Balls"